Human Ipsilateral Motor Physiology and Neuroprosthetic Applications in Chronic Stroke

Improving the recovery of lost motor function in hemiplegic chronic stroke survivors is a critical need to improve the lives of these patients. Over the last several decades, neuroprosthetic systems have emerged as novel tools with the potential to restore function in a variety of patient populations. While traditional neuroprosthetics have focused on using neural activity contralateral to a moving limb for device control, an alternative control signal may be necessary to develop brain-computer interface (BCI) systems in stroke survivors that suffer damage to the cortical hemisphere contralateral to the affected limb. While movement-related neural activity also occurs in the hemisphere ipsilateral to a moving limb, it is uncertain if these signals can be used within BCI systems. This dissertation examines the motor activity ipsilateral to a moving limb and the potential use of these signals for neuroprosthetic applications in chronic stroke survivors. Patients performed three-dimensional (3D) reaching movements with the arm ipsilateral to an electrocorticography (ECoG) array in order to assess the extent of kinematic information that can be decoded from the cortex ipsilateral to a moving limb. Additionally, patients performed the same task with the arm contralateral to the same ECoG arrays, allowing us to compare the neural representations of contralateral and ipsilateral limb movements. While spectral power changes related to ipsilateral arm movements begin later and are lower in amplitude than power changes related to contralateral arm movements, 3D kinematics from both contralateral and ipsilateral arm trajectories can be decoded with similar accuracies. The ability to decode movement kinematics from the ipsilateral cortical hemisphere demonstrates the potential to use these signals within BCI applications for controlling multiple degrees of freedom. Next we examined the relationship between electrode invasiveness and signal quality. The ability to decode movement kinematics from neural activity was significantly decreased in simulated electroencephalography (EEG) signals relative to ECoG signals, indicating that invasive signals would be necessary to implement BCI systems with multiple degrees of freedom. For ECoG signals, the human dura also causes a significant decrease in signal quality when electrodes with small spatial sizes are used. This tradeoff between signal quality and electrode invasiveness should therefore be taken into account when designing ECoG BCI systems. Finally, chronic stroke survivors used activity associated with affected hand motor intentions, recorded from their unaffected hemisphere using EEG, to control simple BCI systems. This demonstrates that motor signals from the ipsilateral hemisphere are viable for BCI applications, not only in motor-intact patients, but also in chronic stroke survivors. Taken together, these experiments provide initial demonstrations that it is possible to develop BCI systems using the unaffected hemisphere in stroke survivors with multiple degrees of freedom. Further development of these BCI systems may eventually lead to improving function for a significant population of patients

The Stripe 82 Massive Galaxy Project III: A Lack of Growth Among Massive Galaxies

The average stellar mass (Mstar) of high-mass galaxies (Mstar > 3e11 Msun) is expected to grow by ~30% since z~1, largely through ongoing mergers that are also invoked to explain the observed increase in galaxy sizes. Direct evidence for the corresponding growth in stellar mass has been elusive, however, in part because the volumes sampled by previous redshift surveys have been too small to yield reliable statistics. In this work, we make use of the Stripe 82 Massive Galaxy Catalog to build a mass-limited sample of 41,770 galaxies (Mstar > 1.6e11) with optical to near-IR photometry and a large fraction (>55%) of spectroscopic redshifts. Our sample spans 139 square degrees, significantly larger than most previous efforts. After accounting for a number of potential systematic errors, including the effects of Mstar scatter, we measure galaxy stellar mass functions over 0.3 < z < 0.65 and detect no growth in the typical Mstar of massive galaxies with an uncertainty of 9%. This confidence level is dominated by uncertainties in the star formation history assumed for Mstar estimates, although our inability to characterize low surface-brightness outskirts may be the most important limitation of our study. Even among these high-mass galaxies, we find evidence for differential evolution when splitting the sample by recent star formation (SF) activity. While low-SF systems appear to become completely passive, we find a mostly sub-dominant population of galaxies with residual, but low rates of star formation (~1 Msun/yr) number density does not evolve. Interestingly, these galaxies become more prominent at higher Mstar, representing ~10% of all galaxies at Mstar ~ 1e12 Msun and perhaps dominating at even larger masses.Comment: Accepted in Ap

The Data Analysis Pipeline for the SDSS-IV MaNGA IFU Galaxy Survey: Emission-Line Modeling

SDSS-IV MaNGA (Mapping Nearby Galaxies at Apache Point Observatory) is the largest integral-field spectroscopy survey to date, aiming to observe a statistically representative sample of 10,000 low-redshift galaxies. In this paper we study the reliability of the emission-line fluxes and kinematic properties derived by the MaNGA Data Analysis Pipeline (DAP). We describe the algorithmic choices made in the DAP with regards to measuring emission-line properties, and the effect of our adopted strategy of simultaneously fitting the continuum and line emission. The effect of random errors are quantified by studying various fit-quality metrics, idealized recovery simulations and repeat observations. This analysis demonstrates that the emission lines are well-fit in the vast majority of the MaNGA dataset and the derived fluxes and errors are statistically robust. The systematic uncertainty on emission-line properties introduced by the choice of continuum templates is also discussed. In particular, we test the effect of using different stellar libraries and simple stellar-population models on the derived emission-line fluxes and the effect of introducing different tying prescriptions for the emission-line kinematics. We show that these effects can generate large ($>$ 0.2 dex) discrepancies at low signal-to-noise and for lines with low equivalent width (EW); however, the combined effect is noticeable even for H$\alpha$ EW $>$ 6~\AA. We provide suggestions for optimal use of the data provided by SDSS data release 15 and propose refinements on the \DAP\ for future MaNGA data releases.Comment: accepted on A

P-MaNGA : full spectral fitting and stellar population maps from prototype observations

MC acknowledges support from a Royal Society University Research Fellowship.MaNGA (Mapping Nearby Galaxies at Apache Point Observatory) is a 6-yearSDSS-IV survey that will obtain resolved spectroscopy from 3600 Å to10300 Å for a representative sample of over 10,000 nearby galaxies.In this paper, we derive spatially resolved stellar population properties and radial gradients by performing full spectral fitting of observed galaxy spectra from P-MaNGA, a prototype of the MaNGA instrument. These data include spectra for eighteen galaxies, covering a large range of morphological type. We derive age, metallicity, dust and stellar mass maps, and their radial gradients, using high spectral-resolution stellar population models, and assess the impact of varying the stellar library input to the models. We introduce a method to determine dust extinction which is able to give smooth stellar mass maps even in cases of high and spatially non-uniform dust attenuation.With the spectral fitting we produce detailed maps of stellar population properties which allow us to identify galactic features among this diverse sample such as spiral structure, smooth radial profiles with little azimuthal structure in spheroidal galaxies, and spatially distinct galaxy sub-components. In agreement with the literature, we find the gradients for galaxies identified as early-type to be on average flat in age, and negative (- 0.15 dex / Re ) in metallicity,whereas the gradients for late-type galaxies are on average negative in age (- 0.39 dex / Re ) and flat in metallicity. We demonstrate howdifferent levels of data quality change the precision with which radialgradients can be measured. We show how this analysis, extended to thelarge numbers of MaNGA galaxies, will have the potential to shed lighton galaxy structure and evolution.PostprintPeer reviewe

The Morphology of Galaxies in the Baryon Oscillation Spectroscopic Survey

We study the morphology of luminous and massive galaxies at 0.3<z<0.7 targeted in the Baryon Oscillation Spectroscopic Survey (BOSS) using publicly available Hubble Space Telescope imaging from COSMOS. Our sample (240 objects) provides a unique opportunity to check the visual morphology of these galaxies which were targeted based solely on stellar population modelling. We find that the majority (74+/-6%) possess an early-type morphology (elliptical or S0), while the remainder have a late-type morphology. This is as expected from the goals of the BOSS target selection which aimed to predominantly select slowly evolving galaxies, for use as cosmological probes, while still obtaining a fair fraction of actively star forming galaxies for galaxy evolution studies. We show that a colour cut of (g-i)>2.35 selects a sub-sample of BOSS galaxies with 90% early-type morphology - more comparable to the earlier Luminous Red Galaxy (LRG) samples of SDSS-I/II. The remaining 10% of galaxies above this cut have a late-type morphology and may be analogous to the "passive spirals" found at lower redshift. We find that 23+/-4% of the early-type galaxies are unresolved multiple systems in the SDSS imaging. We estimate that at least 50% of these are real associations (not projection effects) and may represent a significant "dry merger" fraction. We study the SDSS pipeline sizes of BOSS galaxies which we find to be systematically larger (by 40%) than those measured from HST images, and provide a statistical correction for the difference. These details of the BOSS galaxies will help users of the data fine-tune their selection criteria, dependent on their science applications. For example, the main goal of BOSS is to measure the cosmic distance scale and expansion rate of the Universe to percent-level precision - a point where systematic effects due to the details of target selection may become important.Comment: 18 pages, 11 figures; v2 as accepted by MNRA

SDSS-IV MaNGA: bulge-disc decomposition of IFU data cubes (BUDDI)

With the availability of large integral field unit (IFU) spectral surveys of nearby galaxies, there is now the potential to extract spectral information from across the bulges and discs of galaxies in a systematic way. This information can address questions such as how these components built up with time, how galaxies evolve and whether their evolution depends on other properties of the galaxy such as its mass or environment. We present bulge–disc decomposition of IFU data cubes (buddi), a new approach to fit the two-dimensional light profiles of galaxies as a function of wavelength to extract the spectral properties of these galaxies’ discs and bulges. The fitting is carried out using galfitm, a modified form of galfit which can fit multiwaveband images simultaneously. The benefit of this technique over traditional multiwaveband fits is that the stellar populations of each component can be constrained using knowledge over the whole image and spectrum available. The decomposition has been developed using commissioning data from the Sloan Digital Sky Survey-IV Mapping Nearby Galaxies at APO (MaNGA) survey with redshifts z 22 arcsec, but can be applied to any IFU data of a nearby galaxy with similar or better spatial resolution and coverage. We present an overview of the fitting process, the results from our tests, and we finish with example stellar population analyses of early-type galaxies from the MaNGA survey to give an indication of the scientific potential of applying bulge–disc decomposition to IFU data

Spectroscopic Constraints on the Buildup of Intracluster Light in the Coma Cluster

The stellar content of the intracluster light (ICL) provides unique insight into the hierarchical assembly process of galaxy clusters. We present optical spectra of three ICL regions (μg ≈25.3-26.2 mag arcsec-²) in the Coma cluster, located between 100 and 180 kpc from their nearest brightest cluster galaxies (BCGs): NGC 4889 and NGC 4874. Integral-field unit (IFU) spectroscopy with 13.5 hr on-source integration was acquired in an ancillary program within the Sloan Digital Sky Survey-IV MaNGA survey. We stacked the 127 individual fiber spectra in each IFU to achieve a 1σ limiting surface brightness of 27.9 mag arcsec-², corresponding to a mean signal-to-noise ratio in the optical of 21.7, 9.0, and 11.7 Å−1, for each ICL region. We apply stellar population models to the stacked spectra. Our results show that the velocity dispersions of ICL regions are very high (σ ~ 630 km s-¹), indicating the stars in these regions are tracing the gravitational potential of the cluster, instead of any individual galaxy. The line-of-sight velocities are different from each other by ~700 km s-¹, while the velocity of each region is similar to the closest BCG. This suggests that the ICL regions are associated with two distinct subclusters centered on NGC 4889 and NGC 4874. The stellar populations of these regions are old and metal-poor, with ages of ${12.7}_{-3.4}^{+1.0}$, ${6.7}_{-2.0}^{+2.9}$, and ${9.7}_{-3.5}^{+3.5}$ Gyr, and [Fe/H] of $-{1.0}_{-0.3}^{+0.2}$, $-{0.6}_{-0.5}^{+0.3}$, and $-{0.8}_{-0.4}^{+0.3}$. From the derived age and metallicity, the buildup of ICL in Coma is likely to be through the accretion of low-mass galaxies or the tidal stripping of the outskirts of massive galaxies that have ended their star formation early on, instead of directly from major mergers of massive galaxies

SDSS-IV MaNGA: the spatial distribution of star formation and its dependence on mass, structure, and environment

We study the spatially resolved star formation of 1494 galaxies in the SDSS-IV MaNGA Survey. Star formation rates (SFRs) are calculated using a two-step process, using H α in star-forming regions and Dn4000 in regions identified as active galactic nucleus/low-ionization (nuclear) emission region [AGN/LI(N)ER] or lineless. The roles of secular and environmental quenching processes are investigated by studying the dependence of the radial profiles of specific star formation rate on stellar mass, galaxy structure, and environment. We report on the existence of ‘centrally suppressed’ galaxies, which have suppressed Specific Star Formation Rate (SSFR) in their cores compared to their discs. The profiles of centrally suppressed and unsuppressed galaxies are distributed in a bimodal way. Galaxies with high stellar mass and core velocity dispersion are found to be much more likely to be centrally suppressed than low-mass galaxies, and we show that this is related to morphology and the presence of AGN/LI(N)ER like emission. Centrally suppressed galaxies also display lower star formation at all radii compared to unsuppressed galaxies. The profiles of central and satellite galaxies are also compared, and we find that satellite galaxies experience lower specific star formation rates at all radii than central galaxies. This uniform suppression could be a signal of the stripping of hot halo gas in the process known as strangulation. We find that satellites are not more likely to be suppressed in their cores than centrals, indicating that the core suppression is an entirely internal process. We find no correlation between the local environment density and the profiles of star formation rate surface density

SDSS-IV MaNGA : constraints on the conditions for star formation in galaxy discs

Funding: Leverhulme Trust Early Career Fellowship (AW)Regions of disc galaxies with widespread star formation tend to be both gravitationally unstable and self-shielded against ionizing radiation, whereas extended outer discs with little or no star formation tend to be stable and unshielded on average. We explore what drives the transition between these two regimes, specifically whether discs first meet the conditions for self-shielding (parameterized by dust optical depth, τ) or gravitational instability (parameterized by a modified version of Toomre’s instability parameters, Qthermal, which quantifies the stability of a gas disc that is thermally supported at T = 104 K). We first introduce a new metric formed by the product of these quantities, Qthermalτ, which indicates whether the conditions for disk instability or self-shielding are easier to meet in a given region of a galaxy, and we discuss how Qthermalτ can be constrained even in the absence of direct gas information. We then analyse a sample of 13 galaxies with resolved gas measurements and find that on average galaxies will reach the threshold for disk instabilities (Qthermal 1). Using integral field spectroscopic observations of a sample of 236 galaxies from the MaNGA survey, we find that the value of Qthermalτ in star-forming discs is consistent with similar behavior. These results support a scenario where disc fragmentation and collapse occurs before self-shielding, suggesting that gravitational instabilities are the primary condition for widespread star formation in galaxy discs. Our results support similar conclusions based on recent galaxy simulations.PostprintPeer reviewe